https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44342 Tue 11 Oct 2022 19:28:24 AEDT ]]> Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45201 P = 3.96 x 10-14). Analysis of 15,588 mother-child pairs shows that the association is driven by fetal rather than maternal genotype. Functional experiments show that the lead SNP, rs7594852, alters the binding of the HIC1 transcriptional repressor. Genes at the locus include several interleukin 1 family members with roles in pro-inflammatory pathways that are central to the process of parturition. Further understanding of the underlying mechanisms will be of great public health importance, since giving birth either before or after the window of term gestation is associated with increased morbidity and mortality.]]> Thu 27 Oct 2022 15:06:39 AEDT ]]> Planning the Human Variome Project: the Spain report https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8177 Sat 24 Mar 2018 08:36:15 AEDT ]]> Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40140 Mon 25 Jul 2022 09:00:17 AEST ]]> Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes. https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54727 Mon 11 Mar 2024 14:11:41 AEDT ]]>